• Just like a chameleon utilizing its
    colored pigments and crystals to
    adapt to its surroundings,
    we proactively pioneer and adapt to
    the everchanging NGS markets with
    our cutting-edge technology to
    support our customer’s needs.

G-Mendeliome Clinical Exome Sequencing

Sensitive Detection of variants with Clinically significant genetic diseases

Hard-to-capture regions available with accurate result

Overview

Celemics’ G-Mendeliome Clinical Exome Sequencing (CES) Panel is
designed to overcome the limitations of analyzing clinical diseases
with conventional whole-exome sequencing.

The CES is a widely used diagnostic method to rapidly and efficiently detect disease-causing
genetic variations within target genes in the human genome.
G-Mendeliome CES panel included clinically significant genes used in various other panels
as well as additional genes, therefore, customers can obtain comprehensive information
of mutations in genes of interest cost-effectively.
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Features &
Benefits

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    Comprehensive genomic profiling of a variety of genetic diseases
    Includes 7,000 genes associated with clinically significant genetic diseases
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    A wide range of target regions
    Includes all clinically significant regions that are not
    covered from competitor panels
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    Cost-effective analysis
    Able to provide accurate analysis with reduced sequencing
    costs compared to WES

Performance

Design of G-Mendeliome CES panel and comparison data

G-mendeliome CES :

Company A + Company B + over 70 genes

The CES Panel was developed from the needs of GC Genome,
the largest clinical NGS service Provider in korea,
to solve the problem of poor diagnosis and high costs

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Coparison data : ZNF419 gene

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Comparison data: COL6A5 gene

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By the in-house manufacturing and probe design system of Celemics, customers can request the sequencing of homolog regions as well as hard-to-capture regions.

The comparison data showed obtained sequencing reads for ZNF419 and COL6A5 genes which commonly masked in other panels.

Example of metagenomic sequencing analysis report

G-Mendeliome CES panel contains around 7,000 disease-related genes as target regions. The related diseases are listed in the table below.

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Higher uniform read depths over GC-rich regions compared to competitor product

Applications

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    Somatic cancer related fields

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    Research for Inherited disease