Customized NGS Panel

Celemics takes NGS Customization to the Next Level

Overview

End-to-end Customized Target Enrichment Panel

Celemics target enrichment panel employs hybridization-based capture technology to enable targeted sequencing, facilitating the analysis of specific regional sequences of entire genomes. It accurately analyzes various types of mutations, including single nucleotide variants (SNVs), insertions/deletions (InDels), copy number variations (CNVs), and rearrangements.

Celemics’ target enrichment panel utilizes our proprietary probe design, rebalancing, blocker, and assay optimization technologies to efficiently analyze not only hard-to-capture areas such as GC-rich and homologous regions, but also tiny amounts of damaged DNA or RNA originated from circulating tumor cells or FFPE samples.

Celemics has successfully developed and delivered over 1,000 custom panels. Our target enrichment approach specifically isolates genomic regions of interest, leading to enhanced sensitivity in detecting genetic mutations through increased coverage with cost-effectiveness.

Customized NGS Panel
Features & Benefits

Industry-leading On-Target Ratio and Uniformity of Hybridization-based Target Enrichment

On-target ratio, uniformity, and great capture performance in GC-rich and homologous regions, even with difficult and small sample amounts, are all important to researchers and clinicians.

Celemics has developed proprietary technologies for probe design, synthesis, blockers, and assay optimization, resulting in best-in-class capture performance.

With our industry-leading performance, customers can increase the sensitivity of the tests and reduce sequencing costs.

Comparison Result

Celemics kit shows much uniform target capture performance, thus enabling high sensitivity and cost reduction

Celemics

Comparison Result

Company A

Comparison Result

This comparison study was performed with same target region, same data amount, and same analysis method.

Exceptional Capture Performance, even in GC-rich and Homologous Regions

GC-rich and homologous regions are often challenging to capture, and some vendors deliberately exclude these regions, making it difficult to analyze important mutations. However, Celemics uses proprietary technology to ensure excellent capture capabilities, even in these areas. We provide custom target region analysis results and discuss all the details with our customers to ensure they don’t miss any important information embedded in these regions.

Comparison Result - GC/AT-rich regions

Celemics panels show superior uniformity across both GC-rich and AT-rich regions compared to Competitor products

Robust Performance of Assessing DNA and RNA Across Various Specimen Quality

Obtaining reliable NGS data from DNA and RNA extracted from FFPE, ctDNA, and specimens with low viral loads can be challenging. However, Celemics’ assay optimization technology enables our customers to analyze such specimens with market-leading performance. Our NGS panel is compatible with poor-quality and low-quantity specimens such as FFPE, solid tumors, ctDNA (liquid biopsy), and more.

Robust performance with low-yield, poor quality FFPE sample

Panel shows robust performance regardless of sample types; even with poor quality and low-input FFPE sample

Experimental condition

  • Sample Type: Highly degraded FFPE samples
  • DNA input: 10 / 50 ng
Robust performance with low-yield, poor quality FFPE sample Panel shows robust performance regardless of sample types; even with poor quality and low-input FFPE sample

Experimental condition

  • Sample Type: Clinical samples
  • DNA input: 50 ng
Robust performance with low-yield, poor quality FFPE sample Panel shows robust performance regardless of sample types; even with poor quality and low-input FFPE sample

Simple Rapid Workflow

Target enrichment workflows are often considered complex and time-consuming. However, Celemics has developed a unique and streamlined workflow that reduces errors, hands-on time, and overall processing time. Our simplified enzymatic library preparation with fast hybridization workflow enables us to reduce both time and internal costs, while maintaining excellent performance.

The conventional NGS workflow typically requires heavy instruments in the process, such as size and amount characterization for library normalization and a vacuum concentrator for hybridization mix concentration. However, Celemics provides a new workflow that eliminates the need for these heavy instruments. Our unique workflow also allows complete walkaway automation, eliminating the need for multiple manual steps that are required with conventional kits that use heavy instruments. With Celemics’ workflow, samples do not need to be taken out from the automation machine until the end of the process, which improves efficiency and reduces errors.

Simple process and workflow of Celemics customized NGS panel

We developed proprietary technologies to provide most affordable, cost-reducing product in the market: Simple enzymatic fragmentation kits with fast hybridization technology with user-friendly Click-to-Report bioinformatics SW

Target
Gene
Selection

Simple process and workflow of Celemics customized NGS panel

Interactive discussion
with customer prior
to panel design

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Elaborate
Design of the
Capture Probe

Integration of
Celemics proprietary
technology for the
best panel performance

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Synthesis of 
the Capture
Probe

Advanced technology for probe synthesis and reagent optimization

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

In-house
Performance
Test

Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Probe
Rebalancing

Able to increase depth and coverage of a specific area by request

Simple process and workflow of Celemics customized NGS panel

Kit
Production

Simple process and workflow of Celemics customized NGS panel

Target
Gene
Selection

Interactive discussion
with customer prior
to panel design

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Elaborate
Design of the
Capture Probe

Integration of
Celemics proprietary
technology for the
best panel performance

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Synthesis of the
Capture
Probe

Advanced technology for probe synthesis and reagent optimization

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

In-hose
Performance
Test

Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Probe
Rebalancing

Able to increase depth and coverage of a specific area by request

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Kit
Production

Simple process and workflow of Celemics customized NGS panel

Target
Gene
Selection

Interactive discussion
with customer prior
to panel design

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Elaborate
Design of the
Capture Probe

Integration of
Celemics proprietary
technology for the
best panel performance

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Synthesis of the Capture
Probe

Advanced technology for probe synthesis and reagent optimization

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

In-hose
Performance
Test

Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Probe
Rebalancing

Able to increase depth and coverage of a specific area by request

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Kit
Production

Simple process and workflow of Celemics customized NGS panel

Interactive discussion
with customer prior to panel design

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Integration of
Celemics proprietary
technology for the best panel performance

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Advanced technology for probe synthesis and reagent optimization

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Detailed QC results
encompassing, Web-lab experiments, NGS runs, and BI analysis provided to customer

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Able to increase depth and coverage of a specific area by request

Simple process and workflow of Celemics customized NGS panel
Simple process and workflow of Celemics customized NGS panel

Real QC of All Customized Panel

Current in-silico methods make it difficult to accurately predict DNA capture levels, which can only be determined through actual demo experiments. It’s important for customers to know their panel’s performance before using it in their laboratory. That’s why all of our customized panels undergo performance validation experiments using reference DNA, and we send the test results to our customers before they begin using them in their laboratory. This allows customer to verify that all the variants of interest are analyzable, to detect any false negatives, and to calculate the number of samples that can be sequenced in a single NGS run.

Easy “Click-to-Report” Bioinformatics Service

We offer the Celemics Analysis Service (CAS) to assist customers in need of bioinformatics support. The CAS system allows for easy data transmission via a single-click and automated upload process. Our team of bioinformatics experts provide complete support, eliminating the need for third-party bioinformaticians. CAS also offers real-time troubleshooting at every stage of analysis, and can be customized according to the specific needs of the client.

In addition, we provide comprehensive clinical interpretation services through a CAP-accredited partner. This service combines bioinformatics algorithms, public data from external sources and knowledge databases, visualization interfaces, and reporting capabilities to deliver a detailed report that includes pathogenicity and drug-associated information.

Provision of White-labeled Customized Product for Supporting Customer’s Business Expansion

We offer white-labeled customized products to support our customers’ business expansion. This means that we can produce customized panels with the customer’s branding and labeling, allowing them to market and sell the product under their own brand. This service provides a cost-effective way for our customers to expand their business while maintaining their brand identity. By partnering with Celemics, customers can leverage our expertise in custom panel development and manufacturing, while also benefiting from our fast turnaround times and consistent high-quality products.

Other Features

Other features image

For Repeated Customized Panel Orders: Highly Uniform Lot-to-lot Quality and Fast Delivery

Highly uniform lot-to-lot quality and fast kit delivery for repeated orders made possible with our 2-step probe manufacturing technology. We ensure every lot of custom panel kits has the same high quality and consistency providing customers with reliable and reproducible results for all orders. Additionally, we offer industry-leading fast delivery for repeated custom panel orders worldwide for fast and efficient sequencing.

Other features image

Gene Add-on Service and Various Reaction Unit Options

We offer customers to add new target genes to their existing panels without having to purchase an entirely new panel.

 

In addition, customers can select from various reaction unit options, allowing efficient, flexible and cost-saving NGS solutions

Other features image

Wide Compatibility with NGS Instruments and Instrument-specific Optimization

Our panels are compatible with various sequencing platforms, such as Illumina, Thermo Fisher, MGI, and Pacific Bioscience. 

 

All Celemics panels allow flexible integration,  optimized with different blockers and assys for each instrument to ensure best possible performance. 

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Resources

Technical Resources

[Product Overview] Celemics Innovative NGS Solutions for Agrigenomics

[Product Overview] Celemics Target Enrichment Panel Overview

[Catalogue] Celemics Products & Service Catalogue_All Products & Service