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OncoRisk Panel

Comprehensive and Specialized for hereditary cancer

31 well-known oncogenes for Hereditary Cancer

Overview

Celemics’ Oncorisk Panel is specifically designed to analyze
hereditary cancer associated genes.

The OncoRisk Panel targets 31 well-known oncogenes, leading to a reduction of total
sequencing cost compared to whole genome sequencing or whole exome sequencing.
Additionally, if the gene of interest does not exist on the panel, it can be added separately
through our gene add-on service.
This flexible design provides cost-effective sequencing results to every customer.
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Features &
Benefits

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    Comprehensive analysis of oncogenes
    Analyze 31 oncogenes associated with inherited cancer and precisely selected
    from Contract Research Organizations and numerous research studies
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    Robust BI system for large deletion analysis
    Receive BI results for large deletion analysis provided by Celemics
    proprietary BI analysis system
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    Used for Homologous Recombination Deficiency (HRD) testing
    Provides information for HRD grade computation to aid precision
    medicine for tumor treatment
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    Market leading performance with sensitivity and specificity
    Detect all types of mutations with over 95% of sensitivity at 5% VAF
    99.9% and 99.5% specificity for SNV and Indel, respectively

Performance

User-Friendly BI analysis report in both variants and CNV Example of variants and CNV analysis results

Gene Mutation Type Amino Acid Change Total Depth REF Depth ALT Depth Variant Allele Frequency
APC SYN p.S1738S 1008 590 415 41.17%
ATM Non-SYN p.D1853N 417 200 217 52.04%
BARD1 Non-SYN p.R658C 829 435 394 47.53%
BMPR1A Non-SYN p.P2T 621 309 311 50.08%
BRCA1 SYN p.S1389S 802 460 342 42.64%
BRCA2 SYN p.V2171V 1026 0 1026 100%
BRIP1 SYN p.Y1137Y 844 3 840 99.53%
PMS2 Non-SYN K541E 686 0 646 100%
PRSS1 SYN p.N246N 921 0 921 100%
PRSS1 Non-SYN p.R53Q 971 0 971 100%

This example of variant analysis results include AA change, mutation type, total sequencing depth, allele frequency, etc.

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  • Example of CNV analysis results (CDKN2A) for specific target regions
  • Higher sequencing depths in the target regions, enabling accurate CNV analysis

Various target genes to comprehensive cancer research

OncoRisk
Panel
APC ATM BARD1 BLM BMPR1A BRCA1 BRCA2 BRIP1 CDH1 CDK4 CDKN2A CHEK2 EPCAM
MLH1 MRE11A MSH2 MSH6 MUTYH NBN PALB2 PMS2 PRSS1 PTEN RAD50 RAD51C RAD51D
SLX4 SMAD4 STK11 TP53 VHL

Applications

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    Germline-related cancer research