Celemics signs an agreement to supply BTSeq™ to Sangon Biotech Co., Ltd., a Chinese genetic analysis company

Celemics signs a supply agreement for BTSeq™ solution with Chinese Sanger sequencing service company

Celemics, South Dakota State University, announce partnership for the development of Hybridization NGS-based Multiple Swine Pathogen Co-Detection Panel

Celemics, Strand Life Sciences Partner on Integrated Platform for NGS Analysis

Celemics: Not All NGS Companies Are the Same
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Targeted Methylation Sequencing Panel

Reveals the Methylation status of Genomic Regions

Accelerating High-quality Analysis & Compatible with a variety of sample types

Overview

Celemics’ proprietary dual probe design containing bisulfite conversion allows accurate analysis of methylation status of target genes. Celemics' methylation sequencing panel provides unparalleled performance for methylation status analysis for plasma DNA. The characteristics of our Methyl-seq panel guarantee comprehensive results for both
the clinical diagnostic and research fields.
  • Step 01

    Sample DNA

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  • Step 02

    Bisulfite conversion

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  • Step 03

    Pre-PCR

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  • Step 04

    Making Panels

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Features &
Benefits

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    Industry-leading capture performance
    Elaborate design considering the sequence alteration by bisulfite conversion
    Thorough comparison analysis of the sequences before and after bisulfite conversion enabling accurate detection of methylation sites
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    Compatible with all sample types
    Perform methylation analysis with gDNA and cfDNA
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    Celemics’ BI analysis service for Methyl-seq
    Celemics proprietary deduplication algorithm allows
    accurate sequencing results
    Visualized results is provided to all results from methylation sequencing panel
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    High reproducibility and concordance of clinical information
    Same methylation patterns when repeatedly tested with the same sample
    Visualized clustering result from pattern analysis showed
    high concordance with the clinical data information.

Workflow

Workflow of Celemics’ Targeted methylation sequencing

Standard Workflow of Targeted Methyl-seq

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Celemics Proprietary Probe Design for Methyl-seq

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  • Targeted methylation sequencing is processed utilizing a bisulfite conversion process in the NGS workflow.
  • The hybridization probe and methylated adapters are designed considering the sequence alteration by bisulfite conversion
  • Only selective genes can be targeted for the analysis, allowing for cost-effective sequencing.

BI analysis for methylation sequencing

Standard Analysis Pipeline for Targeted Methyl-seq

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  • Customers who are new to methylation analysis can be supported by Celemics' in-house bioinformatics software service for fast and accurate analysis.
  • Comparison between C/T panel and G/A panel allows accurate discovery of methylation patterns of CpG, CHH, and CHG regions in targeted gene

Applications

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    Cancer-related epigenetics

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    Researches for gene activation

Resources