CelemicsㅣInnovates NGS-Based Materials with novel sequencing technology

NGS Target Enrichment Panel

Superior performance with flexible customization

Overview

“Unlike Whole Genome Sequencing, Targeted Sequencing is a
technique that selectively analyzes specific regional sequences
of genomes.”

Our Target Enrichment Panel uses hybridization-based capture technology to enable the core
process of Target Sequencing, which is the separation and analysis of specific regional sequences
of entire genomes. It can also accurately analyze all types of mutations, such as SNV, InDel, CNV,
and Rearrangement.

Celemics’ Target Enrichment Panel utilizes our intrinsic probe design, rebalancing, and molecular
barcode technologies to efficiently analyze not only hard-to-capture areas such as GC-rich and
homologous regions but also tiny amounts of damaged DNA or RNA originated from circulating
tumor cells or FFPE samples.

Technologies

Probe design technology

Rebalancing &
Molecular barcode technology

Analysis of GC-rich and
homologous regions

Minuscule amounts of
DNA and RNA analysis

Service

For all Customized and Ready-to-Use Panels, Celemics uses standard DNA samples to run
product QC for wet-lab tests, NGS runs, and bioinformatics up to the standard of the actual
product used by our clients, and also provide detailed QC information as well.

Through this process, we can reduce both the possibility of experimental failure and the time
and costs involved with our clients evaluating the products themselves. Additionally, through
our proprietary 2-step mass production technology, we can manufacture high quality
reproducible customized panels, which makes first-time-use clients to have their subsequent orders.

Celemics’ Target Enrichment Panel is compatible with all currently available NGS equipment,
such as Illumina, Thermo Fisher Scientific, Pacific Bioscience, and MGI, and provides
bioinformatics software for data analysis.

Features &
Benefits

Industry-leading capture performance
Industry-leading on-target ratio, coverage and uniformity
High performance, even in areas difficult to analyze
While other companies purposely mask hard-to-capture
areas such as GC-rich and homologous regions, making
important mutation analysis difficult, Celemics uses our
proprietary technology to guarantee excellent capture
capabilities, even in these areas.
Extremely small amounts of damaged
DNA/RNA applicable
Accurate analysis possible with amounts as small as 20ng
High performance even with damaged samples such as
FFPE and cfDNA
Pre-capture pooling applicable
Capable of analyzing several sample libraries through one
capture by attaching sample indices beforehand when
creating libraries, significantly decreasing experimental
hands-on time and cost.
Provision of molecular barcode kits and bioinformatics
Provision of molecular barcode kit specifically developed to
detect mutations in samples with minuscule amounts, such
as cfDNA and bioinformatics algorithm that eliminates
duplicates and generates consensus sequences
Gene Add-on service for expending the panels
Decrease of novel panel development time and cost
through the addition of newly discovered genes or
general panel expansion to already existing client panels
Compatible with all NGS Equipment
Compatible with all NGS devices from Illumina, Thermo
Fisher Scientific, Pacific Bioscience and MGI
Support of enzymatic DNA fragmentation
Enabling of experimentation without specific gDNA
shearing equipment through the support of ultrasonic-based
mechanical shearing and enzymatic fragmentation
Bioinformatics SW provision
Provision of bioinformatics SW that processes raw NGS data
(FASTQ) to identify characteristics such as mutation type,
VAF and pathogenicity for customer’s convenience
Real QC of all customized panels
Celemics is the only company to provide detailed QC
information for all wet-lab experiments, NGS runs and
bioinformatics using standard DNA samples
when developing Customized Panels
High, uniform lot quality for repeated orders
Provision of customized panels of equally high quality to
clients making subsequent orders using proprietary 2-step
mass production technology

Applications

  • Targeted DNA/RNA sequencing
  • Germline, somatic mutation analysis
  • Liquid biopsy analysis (ctDNA)
  • Multiple gene expression analysis
  • High-throughput genotyping
  • Integration-site sequencing