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  Home > PRODUCT > Targeted Sequencing Kit > Hereditary Cancer Kit
Hereditary Cancer Kit
Our Hereditary Cancer testing panel is designed to analyze 31 genes related to breast, ovarian, colorectal, endometrial, melanoma, pancreatic, gastric, prostate and lung cancers. Our panel specifically isolates CDS regions of 31 oncogenes, thereby increasing the detection sensitivity of genetic mutations.
※ Research Use Only. Not for human or animal therapeutic or diagnostic use.
 
  GENERAL INFORMATION
Assay Genes
APC, ATM, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PRSS1, PTEN, RAD50, RAD51C, RAD51D, SLX4, SMAD4, STK11, TP53, VHL
Variants
SNV, InDel, CNV
Target Region
Whole CDS (+/- 30 bp) region (Target size: 97kb)
Applicable NGS platform
Illumina           HiSeq / NextSeq / MiSeq
Ion Torrent     PGM, Proton
 
  PRODUCT COMPOSITION
Standard Kit
Library Preparation Kit + Adaptors and Index Primers Set + Hereditary Cancer Target capture reagent (Probe, Hyb. Reagent and Wash Buffers)
All-in-one Kit
Standard Kit + TopQXSEP MagBead + Streptavidin Bead
 
  PRODUCT LIST
• All-in-one Kit for Illumina
Cat.no.
Quantity
 
AIOR16
OncoRisk kit (16rxn)
AIOR24
OncoRisk kit (24rxn)
AIOR48
OncoRisk kit (48rxn)
AIOR96
OncoRisk kit (96rxn)
 
• All-in-one Kit for Proton & PGM
Cat.no.
Quantity
 
APOR16
OncoRisk kit (16rxn)
APOR24
OncoRisk kit (24rxn)
APOR48
OncoRisk kit (48rxn)
APOR96
OncoRisk kit (96rxn)
 
• Standard Kit for Illumina
Cat.no.
Quantity
 
SIOR16
OncoRisk kit (16rxn)
SIOR24
OncoRisk kit (24rxn)
SIOR48
OncoRisk kit (48rxn)
SIOR96
OncoRisk kit (96rxn)
 
• Standard Kit for Proton & PGM
Cat.no.
Quantity
 
SPOR16
OncoRisk kit (16rxn)
SPOR24
OncoRisk kit (24rxn)
SPOR48
OncoRisk kit (48rxn)
SPOR96
OncoRisk kit (96rxn)
※ If you want some sample, please send an e-mail to Celemics technical support team (support@celemics.com).
 
  HOW TO PROCEED
Order
Quotation
(in 1 business day)
Payment
Shipment
 
  SAMPLE REQUIREMENT
Please send your inquiry for any samples which do not satisfy the minimum requirements described below. Samples should be prepared according to the guide below.
 
A. Human genomic DNA extracted from blood, tissue, saliva
 
Amount
Concentration
Purity
≥ 200 ng
≥ 10 ng/ul
A260/A280 = 1.8 - 2.0
※ Fluorometric quantitation method is employed to measure the amount of sample above (ex. Qubit, PicoGreen).
 
B. Human genomic DNA extracted from FFPE; Formalin-Fixed Paraffin-Embedded
Please send your inquiry for FFPE experiments to Celemics technical support team (support@celemics.com).
 
* Important Note
- For strongly degraded templates, such as FFPE samples, Celemics recommends to submit highest possible amount.
- And sequencing result may vary according to the quality of samples applied to a test.
 
* Additional Note
- Genomic DNA should be eluted in pure sterile water or TE buffer.
- Research use only
 
  REFERENCE
The chart below illustrates specific genetic mutations which increase the potential risk of developing certain cancers.
 
(Ref 1) Hwang, S.J., et al., Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk. < Am J Hum Genet, 2003. 72(4): p. 975-83.>
(Ref 2) Pharoah, P.D., et al., Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. <Gastroenterology, 2001. 121(6): p. 1348-53>
 
  TURNAROUND TIME
Domestic
2~3 Weeks
International
3~4 Weeks
 
  FOR YOUR BETTER EXPERIMENT....

TopQXSEP MagBead
All-in-one
Library Preparation Kit
 
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